Chronic myelogenous leukemia (CML) is a type of cancer that affects the bone marrow and blood cells. It is characterized by the uncontrolled growth of abnormal white blood cells called myeloid cells.
CML is caused by a genetic mutation known as the Philadelphia chromosome, which occurs when two genes, BCR and ABL1, fuse together. This fusion gene produces an abnormal protein called BCR-ABL1, which signals the white blood cells to grow and divide continuously.
The symptoms of CML can vary depending on the stage of the disease,
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