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Plasma cell neoplasms, including multiple myeloma, are a group of cancers that originate from plasma cells, which are a type of white blood cell involved in the immune response. These neoplasms occur when abnormal plasma cells divide and grow uncontrollably, leading to the formation of tumors.

Multiple myeloma is the most common type of plasma cell neoplasm. It is a cancer of the plasma cells that typically affects older individuals. The exact cause of multiple myeloma is unknown.