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Pancreatic neuroendocrine tumors (PNETs) are a rare type of cancer that develops in the hormone-producing cells of the pancreas known as islet cells. These tumors are also called pancreatic islet cell tumors or pancreatic neuroendocrine neoplasms.

PNETs can be functioning or non-functioning. Functioning tumors produce hormones, leading to specific symptoms, while non-functioning tumors do not produce hormones and may not cause any noticeable symptoms until they grow large enough to cause pressure on surrounding organs.